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Medically reviewed by University of Illinois-Chicago, Drug Information Group on May 22, 2018 — Written by University of Illinois-Chicago, Drug Information Group
Important warningsAboutSide effectsInteractionsOther warningsDosageTake as directedImportant considerationsAlternatives
Highlights for medroxyprogesterone
Medroxyprogesterone injection is a hormone medication that’s available as three brand-name drugs:Depo-Provera, which is used to treat kidney cancer or cancer of the endometriumDepo-Provera Contraceptive Injection (CI), which is used as birth controlDepo-subQ Provera 104,which is used as birth control or as treatment for endometriosis painDepo-Provera and Depo-Provera CI are available as generic drugs. Depo-subQ Provera 104 is not available as a generic drug.Medroxyprogesterone comes in two forms: an oral tablet and an injectable suspension. The injection is given by a healthcare provider at a clinic or hospital.
This drug has black box warnings. These are the most serious warnings from the Food and Drug Administration (FDA). Black box warnings alert doctors and patients about drug effects that may be dangerous.Decreased bone mineral density warning:Medroxyprogesterone may cause a major decrease in bone mineral density in females. This causes a decrease in bone strength. This loss is greater the longer you use this drug, and may be permanent. Do not use medroxyprogesterone as birth control or treatment for endometriosis pain for longer than two years. It’s not known if this effect may increase the risk of fracture due to osteoporosis later in life.No STD protection warning:Some forms of this drug are used to prevent pregnancy. However, all forms of this drug do notprovide any protection against HIV infection or other sexually transmitted diseases.
Blood clots warning:Medroxyprogesterone raises your risk of blood clots. These clots can occur anywhere in your body. These could be fatal (cause death).Ectopic pregnancy warning:Women who become pregnant while using this drug are at risk of ectopic pregnancy. This is when a fertilized egg implants outside of your uterus, such as in one of your fallopian tubes. Call your doctor right away if you have severe pain in your abdomen (stomach area) while taking this drug. This can be a symptom of ectopic pregnancy.
What is medroxyprogesterone?
Medroxyprogesterone injection is a prescription drug. It’s given by a healthcare provider at a clinic or hospital. You or your caregiver won’t be able to administer this drug at home.
Medroxyprogesterone injection is available as the brand-name drugs Depo-Provera, Depo-Provera CI, or Depo-subQ Provera 104. Depo-Provera and Depo-Provera CI are also available as generic drugs. Depo-subQ Provera 104 is not. Generic drugs usually cost less than brand-name versions. In some cases, they may not be available in every strength or form as brand-name drugs.